VariantDB is a web based interactive annotation and filtering platform that automatically annotates variants with allele frequencies, functional impact, pathogenicity predictions and pathway information. It allows filtering by all annotations, under dominant, recessive or de novo inheritance models and is therefore a powerful tool to help in the interpretation of next generation genome sequencing data. 

VariantDB is part of WiNGS, the federated platform supporting whole human genome sequencing analysis and interpretation. The tool is developed at the University of Antwerp and published in Genome Medicine (manuscript).